KPV

Alpha-melanocyte-stimulating hormone (alpha-MSH) has two jobs: it darkens skin and it calms inflammation. Researchers found that the anti-inflammatory effect lives largely in its last three amino acids, lysine, proline and valine, which became the tripeptide KPV.KPV enters cells through PepT1, a transporter found in the gut lining, and there it dampens NF-κB, a master switch of inflammation, along with inflammatory signals such as TNF-α and IL-1β. In a study published in Gastroenterology (2008), KPV reduced intestinal inflammation in mice with colitis, and it has been studied in models of inflammatory bowel disease and a leaky gut.It is also studied in skin, wound healing and the gut-skin axis. PeptiLab supplies KPV at 10 mg, as a vial (reconstituted or dry, your choice) or a disposable pre-filled pen. It also appears in our Glow and Repair stacks.

• The anti-inflammatory core of alpha-MSH, without the tanning effect
• Dampens NF-κB, a master switch of inflammation, in research models
• Reduced colitis in mice (Gastroenterology, 2008)
• Gut and skin: studied for barrier function on both fronts
• 10 mg, as a vial or a ready-to-use pen

Reviewed by PeptiLab editorial team · 25 September 2026

• A calmer gut: less bloating and discomfort, users report
• Lower overall inflammation on a daily protocol
• Calmer, clearer skin as a knock-on effect of the gut-skin axis
• Pairs with BPC-157 + TB-500 in our Repair stack

Collected from open discussions in the peptide community. Everyone's experience is their own.

• Anti-inflammatory: dampens NF-κB, TNF-α and IL-1β in research models
• Gut barrier: enters gut cells through the PepT1 transporter
• Colitis models: reduced intestinal inflammation in mice (Gastroenterology, 2008)
• Skin: studied for wound healing and the gut-skin axis

C-terminal tripeptide (Lys-Pro-Val) of alpha-MSH, associated in research with inhibition of NF-κB signalling and reduced pro-inflammatory cytokine expression.

Store refrigerated at 2–8°C, away from light.

Free delivery across Bali on orders from Rp 3.000.000, and on every stack. Below that, delivery is Rp 100.000. Same-day delivery across Bali; the manager confirms the exact time. Payment is made after a manager contacts you and confirms the order; no payment is taken on this site.